Only if it is a 99-03 7.3L Powerstroke, 99-06 GM gas, or 01-05 Duramax. All others do not need any fuses pulled unless otherwise specified.
1999-2001 7.3L Powerstroke: pull fuses 16, 19, and 29. Once the download is complete, reinstall all fuses.
2002-2003 7.3L Powerstroke: pull fuses 19, 35, and 41. Once the download is complete, reinstall all fuses.
2001-2002 Duramax: pull fuses SEO IGN, RDO1, RAP2. Once the download is complete, reinstall all fuses.
2003-2005 Duramax: pull fuses: TBC BATT, TBC IGN1, RADIO, INFO. Once the download is complete, reinstall all fuses.
Duramax Fuses
Replace all Fuses after the Download is Complete!